tag:blogger.com,1999:blog-1892134081049774386.post3270624176339642226..comments2023-12-02T09:37:08.472-05:00Comments on Autism Jabberwocky: Validating the Extreme Male Brain Theory of AutismM.J.http://www.blogger.com/profile/12033918835169823548noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-1892134081049774386.post-91276515437695844502014-10-14T01:15:12.048-04:002014-10-14T01:15:12.048-04:00Men and women with autism are both keen systemizer...Men and women with autism are both keen systemizers, but less able empathizers.<a href="http://www.aschealthcare.co.uk/our-centre/the-breightmet-centre" rel="nofollow">adult autism</a> is related to overexposure to testosterone while in the womb.The new study included adults between 18 and 75 years of age. The participants with autism are all high-functioning, and the control group excludes people with any condition that can alter perception of reality, such as bipolar disorder, epilepsy or schizophrenia.ASC Healthcarehttps://www.blogger.com/profile/03877781011634519606noreply@blogger.comtag:blogger.com,1999:blog-1892134081049774386.post-69157980703390617562012-05-29T12:27:22.499-04:002012-05-29T12:27:22.499-04:00BAP tests have been conducted in Down syndrome wit...BAP tests have been conducted in Down syndrome with autism featuring the interplay between a de novo genetic mutation and a background BAP genetic effect that follows a developmental trajectory to an autism diagnosis. Ghaziuddin compared a group of Downs Syndrome individuals and their first degree relatives (parents and siblings) with or without a diagnosis of autism. In Downs Syndrome with autism there was an excess of first degree relatives who met the description of BAP features compared to first degree relatives in Downs Syndrome children without autism who did not. The Downs Syndrome mutation and autism was not present in first degree relatives, parents and siblings, and the genes underlying the BAP component part are independent of and is a background genetic effect acting on the neuroanatomical alterations associated with intellectual disability (ID) in Downs Syndrome ( Ghaziuddin 2000 ) ( Ghaziuddin 1997 ).<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/11079353<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/9089464RAJhttps://www.blogger.com/profile/17686665037607780553noreply@blogger.comtag:blogger.com,1999:blog-1892134081049774386.post-39130706757272788552012-05-25T22:07:16.221-04:002012-05-25T22:07:16.221-04:00Thanks for this MJ. I'd like to see these kind...Thanks for this MJ. I'd like to see these kinds of studies go one step further. I'd like to see the mothers of these HFA kids undertake the Broad Autism Phenotype test to see if they exhibit any ASD characteristics.sharon Morrishttps://www.blogger.com/profile/15492764403059640967noreply@blogger.comtag:blogger.com,1999:blog-1892134081049774386.post-9960630568116233402012-05-24T07:40:51.234-04:002012-05-24T07:40:51.234-04:00All human neonates during the first year of life u...All human neonates during the first year of life undergo what is known as the 'neonatal testosterone surge' During the surge, increased production of testosterone occurs, higher in males than in females.<br /><br />Birth aspyxia is a known autism risk factor. Induced birth aspyxia (global birth hypoxia)in mice produced increased levels of testosterone production during the neonatal testerone surge in male and female mice. Over time the testostorone surge subsides and testosterone production tends to normalize. When normalization occurs measuring testosterone levels in puberty, adolescence and in adults may be uninformative.<br /><br />General population studies that apply Baron-Cohen's AQ scores indexed by Apgar scores is warrented. I have a paper under peer review exploring this very topic. <br /><br /><br />References <br /><br />Boksa P, Zhang Y. (2008). Global birth hypoxia increases the neonatal testosterone surge in the rat. Neuroendocrinology.88(4):266-75. <br /><br />http://www.ncbi.nlm.nih.gov/pubmed/18594128<br /><br />Jensen RA (2012). Brief Report: Klinefelter Syndrome and XYY Syndrome: The extreme male brain theory of autism and the role of early testosterone production in brain development and behavior. Under review.RAJhttps://www.blogger.com/profile/17686665037607780553noreply@blogger.comtag:blogger.com,1999:blog-1892134081049774386.post-89783369594328209982012-05-20T10:01:17.378-04:002012-05-20T10:01:17.378-04:00Thanks for the link, I hadn't seen that one ye...Thanks for the link, I hadn't seen that one yet. I have seen a bunch of papers over the years that suggested that endocrine disruptors might play a role in autism but not too many that actually measured results in people with autism.M.J.https://www.blogger.com/profile/12033918835169823548noreply@blogger.comtag:blogger.com,1999:blog-1892134081049774386.post-30533203014372266762012-05-20T09:49:01.914-04:002012-05-20T09:49:01.914-04:00There was a study about a month ago that looked at...There was a study about a month ago that looked at testosterone in a high functioning adults and found that men had a normal level while women had an elevated level. But the women also showed an increased level of dehydroepiandrosterone sulfate which is involved (in some way) in the pathway pictured above.<br /><br />http://autismjabberwocky.blogspot.com/2012/04/study-extreme-male-brain-theory-of.html<br /><br />Or in other words, yes, there are some limited signs that the pathway is still unbalanced in adult women with autism.<br /><br />As for the size of the groups, I'm not sure. I would guess that they wanted to make sure that levels for the control group were really the normal value instead of just a sampling error.M.J.https://www.blogger.com/profile/12033918835169823548noreply@blogger.comtag:blogger.com,1999:blog-1892134081049774386.post-44706010082684967772012-05-20T09:26:02.686-04:002012-05-20T09:26:02.686-04:00I would like it if we started finding out just how...I would like it if we started finding out just how many mothers have hormonal imbalances or other biological problems such as immune disruption. We need more studies like this one - http://marbles.ucdavis.edu/ - but not limited to just autism.M.J.https://www.blogger.com/profile/12033918835169823548noreply@blogger.comtag:blogger.com,1999:blog-1892134081049774386.post-80382130485819509822012-05-20T04:01:08.923-04:002012-05-20T04:01:08.923-04:00Well y'know there is some preliminary evidence...Well y'know there is some preliminary evidence that endocrine disruptors like phthalates might be implicated in autism as per the recent finding of elevated levels: <br />http://www.asnneuro.org/an/imps/pdf/AN20120015.pdf (full-text)<br />It's not proof of anything aside from the fact that a small group of people with autism seem to be better excretors of some of these compounds, but certainly it asks some interesting questions...Paul Whiteleyhttps://www.blogger.com/profile/14288851488012254897noreply@blogger.comtag:blogger.com,1999:blog-1892134081049774386.post-81387684362031126412012-05-19T21:54:18.561-04:002012-05-19T21:54:18.561-04:00I wonder if they controlled for the differences in...I wonder if they controlled for the differences in life-style and social contacts among the autistics versus the controls that could maybe cause these hormones to go out of whack later in life and not just during fetal development, infancy or shortly afterwards. <br /><br />I wonder why the control group was so much larger than the autistic group.jonathanhttps://www.blogger.com/profile/14972394536850151087noreply@blogger.comtag:blogger.com,1999:blog-1892134081049774386.post-67462894793906312572012-05-19T18:16:20.516-04:002012-05-19T18:16:20.516-04:00Interesting...It would also be interesting to see ...Interesting...It would also be interesting to see what health issues would cause mum to have hormones out of whack that predispose offspring to autism, such as the pill, undiagnosed celiacs, the crap in our environment, etc.Mrs. Edhttps://www.blogger.com/profile/02144247274657295271noreply@blogger.com